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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TK1
All Species:
35.15
Human Site:
Y181
Identified Species:
85.93
UniProt:
P04183
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P04183
NP_003249.3
234
25469
Y181
V
I
G
G
A
D
K
Y
H
S
V
C
R
L
C
Chimpanzee
Pan troglodytes
XP_001145198
309
32942
Y256
V
I
G
G
A
D
K
Y
H
S
V
C
R
L
C
Rhesus Macaque
Macaca mulatta
XP_001107944
234
25438
Y181
V
I
G
G
A
D
K
Y
H
S
V
C
R
L
C
Dog
Lupus familis
XP_540462
242
26432
Y181
V
I
G
G
A
D
K
Y
H
S
V
C
R
L
C
Cat
Felis silvestris
Mouse
Mus musculus
P04184
233
25757
Y181
V
I
G
G
A
D
K
Y
H
S
V
C
R
L
C
Rat
Rattus norvegicus
P27158
121
13492
V91
V
A
Q
E
A
L
G
V
A
V
I
G
I
D
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521037
255
27396
Y203
V
I
G
G
A
D
K
Y
H
A
V
C
R
V
C
Chicken
Gallus gallus
P04047
224
24853
Y182
V
I
G
G
A
D
K
Y
H
S
V
C
R
A
C
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_956126
230
25567
Y182
V
I
G
G
S
D
K
Y
H
A
V
C
R
C
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784788
227
25150
Y174
I
I
G
G
A
D
K
Y
M
A
V
C
R
D
C
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
75.7
98.7
89.2
N.A.
87.1
47
N.A.
72.9
73
N.A.
65.8
N.A.
N.A.
N.A.
N.A.
48.7
Protein Similarity:
100
75.7
99.1
90.9
N.A.
91.8
50
N.A.
78
82
N.A.
74.7
N.A.
N.A.
N.A.
N.A.
62.8
P-Site Identity:
100
100
100
100
N.A.
100
13.3
N.A.
86.6
93.3
N.A.
80
N.A.
N.A.
N.A.
N.A.
73.3
P-Site Similarity:
100
100
100
100
N.A.
100
20
N.A.
100
93.3
N.A.
93.3
N.A.
N.A.
N.A.
N.A.
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
90
0
0
0
10
30
0
0
0
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
90
0
10
90
% C
% Asp:
0
0
0
0
0
90
0
0
0
0
0
0
0
20
0
% D
% Glu:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
90
90
0
0
10
0
0
0
0
10
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
80
0
0
0
0
0
0
% H
% Ile:
10
90
0
0
0
0
0
0
0
0
10
0
10
0
0
% I
% Lys:
0
0
0
0
0
0
90
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
10
0
0
0
0
0
0
0
50
0
% L
% Met:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
90
0
0
% R
% Ser:
0
0
0
0
10
0
0
0
0
60
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
90
0
0
0
0
0
0
10
0
10
90
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
90
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _